DDMB-MS18

# Mathematical Modeling of Exposure and Target Interaction in Pharmaceutical Development of Therapeutic Proteins

#### Thursday, June 17 at 04:15am (PDT)

Thursday, June 17 at 12:15pm (BST)

Thursday, June 17 08:15pm (KST)

**Organizers:**

#### Jeroen Elassaiss-Schaap (PD-value BV, Netherlands), Johannes Schropp (University of Konstanz, Germany)

**Description**:

The use of mathematical modeling in pharmaceutical sciences began more than 50 years ago with the use of differential equations to quantify plasma drug disposition (pharmacokinetics) and drug exposure effects (pharmacodynamics). Under increasing computing power and statistical advances, more complex models and methods have been developed to address challenging problems in this field. One of the applications is in the research on therapeutic proteins. Advances in bio-genetic engineering have amplified the industrial efforts spent on developing proteins as medicines. These therapeutics have their own demands on modeling approaches, such as feedback loops between pharmacokinetics and pharmacodynamics labeled target-mediated drug disposition and interesting dual pharmacology of bispecific antibodies. The pharmacokinetic properties of therapeutic proteins furthermore allow excellent predictions using physiology-based pharmacokinetic models. The organization of this mini-symposium is initiated by the Mathematical and Computational Sciences Special Interest Group of the International Society of Pharmacometrics. This group strives to strengthen the mathematical perspective in pharmacometrics: the interplay of pharmacology, biology and statistics, among else by seeking collaboration with related fields. This mini-symposium covers related mathematical topics in the pharmacology of antibodies, with the intent of seeking common grounds with the SMB community and initiate further collaboration between our disciplines.

#### Leonid Gibiansky

*(QuantPharm LLC, North Potomac, MD, USA)*

###### "Target-mediated drug disposition in the pharmacokinetics of monoclonal antibodies and its quasi-steady state solutions"

#### Wojciech Krzyzanski

*(University at Buffalo, USA)*

###### "Application of Quasi-equilibrium Approximation to Reduction of Complex Physiologically Based Pharmacokinetic Models of Monoclonal Antibodies"

#### Johannes Schropp

*(University of Konstanz, Germany)*

###### "Bispecific-Antibodies: Properties, Approximation and Optimal Dosing Strategy"

#### Weirong Wang

*(Janssen, USA)*